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. 2018 Sep 12;9:1042. doi: 10.3389/fphar.2018.01042

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Copyright © 2018 Zhang, Fang, Qu, Wu, Wang, Zhang, Ma, Zhang, Huang, Shi, Liang, Gao, Song and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD13 inhibition enhances the cytotoxic effect of 5FU. PLC/PRF/5 cells were transfected with CD13-targeting siRNA. FCS was used to detect CD13 expression (A). (B) The average intensity of fluorescence of one experiment. The results were from a representative of at least three repeated experiments. PLC/PRF/5 and Huh7 cells were treated with CD13-neutralizing antibody, CD13-targeting siRNA, 5FU, a combination of neutralizing antibody and 5FU, and a combination of siRNA and 5FU. Then, ROS level (C) and cell viability (D) were detected. Data represent mean ± SD (n = 3). ^∗P < 0.05 vs. 5FU, ^∗∗P < 0.01 vs. 5FU. The transfection protocol was performed according to the instructions of lipofection 2000.