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. 2018 Sep 12;9:1042. doi: 10.3389/fphar.2018.01042

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Copyright © 2018 Zhang, Fang, Qu, Wu, Wang, Zhang, Ma, Zhang, Huang, Shi, Liang, Gao, Song and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BC-02 inhibits the viability of 5FU-resistant cells. After long period of 5FU incubation, 5FU-resistance PLC/PRF/5 cells (PLC/PRF/5-5FU) can survive at 40 μM 5FU. CD13 expression was detected by FCS (A). The inhibition rate of different drugs at a concentration 100 μM on PLC/PRF/5-5FU cells were determined (B). After MTT was added for 2 h, photographs of cells were taken (C). The IC50 values of different cytotoxic agents on PLC/PRF/5 and PLC/PRF/5-5FU cells were determined using MTT assay. In addition, drug resistance index was calculated using the IC50 value of PLC/PRF/5-5FU cells versus the IC50 value of PLC/PRF/5 cells (D). Data represent mean ± SD (n = 3). ^∗P < 0.05, ^∗∗P < 0.01 vs. 5FU.