Table II.

Therapeutic agents targeting JAK/STAT3 in the glioblastoma setting.

Author, date	Drug name	Target	Findings	(Refs.)
Ashizawa et al, 2013	STX-0119	STAT3	Reduced cell growth and induced apoptosis in vitro and reduced tumour growth in vivo	(30)
Rahaman et al, 2002	WP1066	JAK2/STAT3	Reduced cell growth in vitro and in vivo	(39)
Hussain et al, 2007	WP1066	JAK2/STAT3	Reduced cell growth in vitro and in vivo	(116)
Iwamaru et al, 2007	WP1066	JAK2/STAT3	Reduced cell growth in vitro and in vivo	(117)
Stechishin et al, 2013	WP1066	JAK2/STAT3	Reduced cell growth in vitro and in vivo	(118)
McFarland et al, 2011	AZD1480	JAK1/2	Reduced cell growth and induced apoptosis in vitro, reduced tumour growth in vivo and enhanced survival of mice bearing intracranial tumours	(119)
He et al, 2013	G5-7	JAK2	Reduced cell growth in vitro and in vivo	(120)
Senft et al, 2011	AG490	JAK2	Reduced cell Proliferation, migration and invasion in vitro	(121)
Lo et al, 2008	JSI-124	JAK2/STAT3	Reduced cell growth and induced apoptosis in vitro	(122)
Mukthavaram et al, 2015	SAR317461	JAK2/STAT3	Reduced cell growth and induced apoptosis and autophagy in vitro	(123)
Fuh et al, 2009	LLL3	STAT3	Reduced cell growth and induced apoptosis in vitro and enhanced survival of mice bearing intracranial tumours	(124)
Ball et al, 2011	LLL12	STAT3	Reduced cell growth and migration and induced apoptosis in vitro	(125)
Sai et al, 2012	WP1193	STAT3	Reduced cell growth in vitro and in vivo	(126)
Han et al, 2016	Cpd188	STAT3	Reduced cell growth in vitro and in vivo	(127)

JAK2, Janus kinase 2; STAT3, signal transducer and activator of transcription 3.