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. 2018 Jun 21;46(16):8232–8244. doi: 10.1093/nar/gky562

Figure 6.

Figure 6.

RBPJ preferentially bound at 15 and 65 bp from nucleosome borders. (A) Nucleosome scores and positions were calculated by Danpos using default parameters and were plotted for the indicated groups as a fraction of their distribution. (B) Average nucleosome scores and Alu nucleosome coverage in base pairs (orange line) plotted verses Alu start position relative to the 5′ end of bound nucleosome reveals highest nucleosomes scores and coverage for Alus that start at around −150 or closer relative to the 5′ of nucleosomes for All nucleosomes with MCR (black line) and RBPJ bound subset (red line). (C) Distribution of Alu start sites relative to 5′end of bound nucleosome for all Alu with MCR and RBPJ bound subset reveals that Alus preferentially start at either −150 bp or +10 bp relative to nucleosome border and these are overrepresented in RBPJ bound group. (D) Distribution of MCR motifs relative to nucleosome borders for all Alu bound nucleosomes (black) and the RBPJ bound subset (red line). (E) Model depicting probable Alu positioning and RBPJ binding locations within nucleosome structure. (F) Distribution of the consensus GTGGGA sequence relative to nucleosome borders for all nucleosomes (black) and RBPJ bound subset (red line).