Fig. 4. The docking poses of the two enantiomers of roemerine in complex with the 5-HT2A and 5-HT2C receptors. A and C. The poses of (R)-roemerine enable a π–π interaction with Phe340/328 as depicted by the black dotted lines. B and D. The poses of (S)-roemerine do not allow a π–π interaction with Phe340/328. For the purpose of clarity, only the principal binding residues are depicted and some of the transmembrane helices are not shown.
