Table II.
Multivariate analysis of factors associated with overall and disease-free survival rates of hepatocellular carcinoma following curative surgical resection.
| Overall survival | Disease-free survival | |||
|---|---|---|---|---|
| Characteristic | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Tumor size, cm | ||||
| >5 vs. ≤5 | 2.81 (1.32–5.98) | 0.007a | 1.96 (1.03–3.74) | 0.040a |
| Tumor number | ||||
| Solitary vs. multiple | 1.15 (0.42–3.13) | 0.791 | NA | NA |
| Vascular tumor thrombus | ||||
| Yes vs. no | 0.84 (0.42–1.68) | 0.626 | 1.12 (0.62–2.05) | 0.704 |
| Tumor differentiation | ||||
| III–IV vs. I–II | 2.00 (0.97–4.11) | 0.059 | NA | NA |
| TNM stage | ||||
| III–IV vs. I–II | 2.36 (0.79–7.12) | 0.126 | 1.67 (0.78–3.56) | 0.188 |
| GGT, U/l | ||||
| >91 vs. ≤91 | 2.60 (1.40–4.82) | 0.002a | 1.70 (0.95–3.05) | 0.075 |
| S100A12 expression | ||||
| Low vs. high | 3.17 (1.53–6.57) | 0.002a | 2.53 (1.29–4.96) | 0.007a |
a
P<0.05. HR, hazard ratio; CI, confidence interval; NA, not adopted; TNM, tumor-node-metastasis; GGT, γ-glutamyltranspeptidase.