Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 10;46(16):8143–8152. doi: 10.1093/nar/gky604

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 3. — E-PCA applied to chr21 TAD imaging data reveals modes of chromosome fluctuation across individual IMR90 cells. The displacement matrix view of PC1, PC2, PC3 of E-PCA are shown in (A–C). PC1 from MI-PCA on the same system is shown as a bar-graph at left and TAD elements are colored according to general domains detected by E-PCA. The corresponding 3D representations are shown in (D–F), where the values of displacement matrix elements are used to color cylinders that connect TADs and . Less significant relationships (cutoff is ) are not shown. The reference 3D path of the 34 TADs (the configuration detected for a chosen cell, cell #1) is shown in (G) along with a reference for the genomic position of each TAD probe. Explanation was made in SI for the selection of cell #1 as the reference.

Inline graphic — E-PCA applied to chr21 TAD imaging data reveals modes of chromosome fluctuation across individual IMR90 cells. The displacement matrix view of PC1, PC2, PC3 of E-PCA are shown in (A–C). PC1 from MI-PCA on the same system is shown as a bar-graph at left and TAD elements are colored according to general domains detected by E-PCA. The corresponding 3D representations are shown in (D–F), where the values of displacement matrix elements are used to color cylinders that connect TADs and . Less significant relationships (cutoff is ) are not shown. The reference 3D path of the 34 TADs (the configuration detected for a chosen cell, cell #1) is shown in (G) along with a reference for the genomic position of each TAD probe. Explanation was made in SI for the selection of cell #1 as the reference.