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. 2018 Aug 7;16(4):4977–4983. doi: 10.3892/ol.2018.9273

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Copyright: © Zhao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Association between SLC6A1 and CDX2 in SK-OV-3 cells. (A) miR-133a mimics inhibited the mRNA expression of SLC6A1 and CDX2. (B) miR-133a inhibitors upregulated the mRNA expression of SLC6A1 and CDX2. miR-133a mimics reduced the relative luciferase activity of the (C) SLC6A1 and (D) CDX2 3′UTRs compared with mutant 3′UTRs. (E) Silencing CDX2 or SLC6A1 with specific siRNAs upregulated miR-133a expression. Results are mean ± standard error of the mean. *P<0.05. SLC6A1, solute carrier family 6 member 1; CDX2, caudal-type homeobox protein 2; miR-133a, microRNA-133a; 3′UTR, 3′-untranslated region; NC, negative control oligo; siCDX2, short interfering RNA targeted at CDX2; siSLC6A1, short interfering RNA targeted at SLC6A1.