Figure 2.

Enhancement of the mobility potential of iCCA cells by IRS2. The cell migration and cell invasion assays of pCMV-IRS2-transfected and empty vector-transfected (A) RBE, (B) SNU1079, and (C) SSP25 cell lines were compared. The number of cells migrating through the membrane and cells invading through the Matrigel of each cell line are presented. The results indicate that IRS2 can promote cell migration and cell invasion. Data represent the mean ± standard deviation of three independent experiments. iCCA, intrahepatic cholangiocarcinoma; IRS2, insulin receptor substrate 2.