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. 2018 Sep 12;9:1299. doi: 10.3389/fphys.2018.01299

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Copyright © 2018 Boardman, Ireland, Sullivan, Pataky, Fleiss, Gressens and Miron.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dynamic expression of human preterm CSF signature proteins at the gene expression level in microglia following experimental brain injury. (A) Mouse model of developmental white matter injury. (B) Fold change in gene expression in microglia isolated from IL-1β mouse model of developmental white matter injury, values at postnatal (P) day 1, 5, and 10 indicated, with p-values ^∗p<0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001; pro-inflammatory function, anti-inflammatory function, supporting oligodendrocyte lineage responses and myelination, impairing oligodendrocyte lineage responses and myelination. (C–E) Fold change in expression of genes in microglia isolated from IL-1β injury model compared to vehicle control, at postnatal days (P) 1, 5, and 10. Significantly upregulated genes shown in magenta, significantly downregulated genes shown in green. (F) Dynamic regulation of Il1b and Il4 over the course of injury. (G) Fold change in expression over vehicle control for genes associated with impairing myelination (blue) and those supporting myelination (purple).

Inline graphic — Dynamic expression of human preterm CSF signature proteins at the gene expression level in microglia following experimental brain injury. (A) Mouse model of developmental white matter injury. (B) Fold change in gene expression in microglia isolated from IL-1β mouse model of developmental white matter injury, values at postnatal (P) day 1, 5, and 10 indicated, with p-values ^∗p<0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001; pro-inflammatory function, anti-inflammatory function, supporting oligodendrocyte lineage responses and myelination, impairing oligodendrocyte lineage responses and myelination. (C–E) Fold change in expression of genes in microglia isolated from IL-1β injury model compared to vehicle control, at postnatal days (P) 1, 5, and 10. Significantly upregulated genes shown in magenta, significantly downregulated genes shown in green. (F) Dynamic regulation of Il1b and Il4 over the course of injury. (G) Fold change in expression over vehicle control for genes associated with impairing myelination (blue) and those supporting myelination (purple).