Table 1.
Median (IQR) normalized fluorescence intensity of 50 cerebrospinal fluid analytes from term control infants and preterm infants.
| Analyte | Function | Control |
Preterm |
p-Value | |||
|---|---|---|---|---|---|---|---|
| Median | IQR | Q1–Q3 | Median | IQR | |||
| C5a (Hc) |  |
1378.5 | 1382.5 | 680.8–2063.3 | 3592.6 | 2540.3 | 0.001∗∗ |
| CRP | |
28446.4 | 20206.4 | 15120.2–35326.6 | 35217.1 | 18532.5 | 0.133 |
| GM-CSF (Csf2) | |
255.6 | 91.2 | 212.2–303.5 | 330.2 | 284.2 | 0.125 |
| IFNγ |
|
403.2 | 127.0 | 328.4–455.4 | 402.4 | 159.3 | 0.916 |
| IL-1α | |
490.5 | 81.4 | 450.6–532.0 | 581.9 | 546.13 | 0.220 |
| IL-1β |
|
52.1 | 73.3 | 10.0–83.3 | 108.8 | 338.8 | 0.014∗ |
| IL-2 | |
413.1 | 77.8 | 367.7–445.5 | 520.5 | 298.0 | 0.030∗ |
| IL-6 |
|
580.0 | 3259.5 | 413.8–3673.3 | 706.2 | 8133.4 | 0.869 |
| IL-8 | |
19466.8 | 55521.7 | 16192.7–71714.4 | 18370.4 | 79637.3 | 0.707 |
| IL-9 |
|
188.8 | 76.1 | 136.9–213.1 | 242.6 | 233.23 | 0.005∗∗ |
| IL-12p40 | |
62.5 | 87.3 | 22.8–110.1 | 83.3 | 206.6 | 0.167 |
| IL-12p70 | |
164.3 | 80.0 | 110.1–190.0 | 220.1 | 219.8 | 0.177 |
| IL-17A |
|
202.1 | 45.4 | 182.5–227.9 | 296.4 | 225.6 | 0.028∗ |
| IL-17B | |
104.6 | 20.0 | 96.3–116.3 | 107.0 | 125.4 | 0.798 |
| IL-17C | |
508.8 | 99.8 | 456.7–556.5 | 546.2 | 246.9 | 0.052 |
| IL-17F | |
72.5 | 73.2 | 22.8–96.0 | 62.6 | 214.0 | 0.619 |
| IL-18 | |
80.9 | 49.6 | 50.0–81.0 | 101.8 | 129.0 | 0.326 |
| MCP-1 (Ccl2) | |
116104.0 | 10004.9 | 112697.7–122702.6 | 109752.5 | 40956.0 | 0.283 |
| MIP1α (Ccl3) | |
211.5 | 282.6 | 118.0–400.6 | 1054.5 | 4168.5 | 0.015∗ |
| MIP1β (Ccl4) | |
6715.4 | 17113.7 | 5549.0–22562.7 | 26868.7 | 31793.7 | 0.133 |
| PIGF | |
593.2 | 375.6 | 438.0–813.6 | 948.0 | 1180.7 | 0.056 |
| RANTES | |
182.8 | 1590.6 | 115.7–1706.3 | 736.4 | 14673.8 | 0.244 |
| TNFα |
|
1095.9 | 167.4 | 1036.8–1204.2 | 1242.3 | 935.8 | 0.074 |
| TNFβ | |
452.6 | 68.8 | 404.4–473.3 | 504.0 | 380.4 | 0.011∗ |
| uPA | |
8733.4 | 8969.4 | 4470.1–13439.5 | 12527.5 | 18004.0 | 0.149 |
| CD200 |  |
98.9 | 61.3 | 58.4–119.7 | 113.6 | 163.9 | 0.326 |
| IL-4 | |
402.7 | 80.7 | 340.7–421.4 | 430.6 | 176.6 | 0.042∗ |
| IL-5 | |
299.9 | 58.6 | 271.5–330.1 | 301.9 | 258.2 | 0.798 |
| IL-10 |
|
481.6 | 787.9 | 429.1–1216.9 | 917.7 | 6406.5 | 0.341 |
| IL-13 | |
382.8 | 93.4 | 336.2–429.5 | 416.3 | 330.8 | 0.104 |
| Activin-A (INHBA) |
|
238.2 | 62.7 | 204.9–267.6 | 271.1 | 314.6 | 0.257 |
| BDNF | |
101.6 | 18.6 | 95.3–113.9 | 145.8 | 191.5 | 0.024∗ |
| BTC | |
304.7 | 49.3 | 273.3–322.6 | 354.0 | 256.7 | 0.045∗ |
| β-NGF | |
206.4 | 169.2 | 119.1–288.2 | 339.6 | 550.56 | 0.117 |
| NT-3 | |
85.7 | 55.20 | 49.9–105.1 | 106.7 | 147.0 | 0.283 |
| Furin |
|
360.4 | 580.5 | 189.6–770.1 | 464.7 | 995.9 | 0.537 |
| Galectin-3 | |
1598.1 | 1419.0 | 859.2–2278.2 | 1069.9 | 4638.26 | 0.892 |
| IGF-1 | |
2005.4 | 574.4 | 1685.3–2259.6 | 2048.0 | 662.5 | 0.812 |
| Insulin (Ins1) | |
180.6 | 70.3 | 149.0–219.3 | 253.8 | 271.8 | 0.074 |
| SCF (Kitl) | |
346.7 | 287.7 | 230.9–518.6 | 419.4 | 631.8 | 0.326 |
| SPP1 |
|
1209.4 | 1828.0 | 766.5–2594.4 | 3064.4 | 4333.1 | 0.007∗∗ |
| TGFβ |
|
706.2 | 122.0 | 640.7–762.7 | 919.0 | 600.0 | 0.013∗ |
| VEGF-C | |
250.6 | 100.1 | 209.6–309.7 | 233.7 | 312.5 | 0.641 |
| BMP2 | |
191.5 | 168.6 | 100.5–269.1 | 140.3 | 301.7 | 0.752 |
| BMP4 | |
116.1 | 90.1 | 72.4–162.5 | 106.0 | 173.1 | 0.845 |
| BMP7 | |
196.5 | 211.8 | 156.2–232.0 | 246.0 | 221.5 | 0.104 |
| FasL | |
290.1 | 159.6 | 203.1–362.7 | 967.0 | 1484.7 | 0.001∗∗ |
| Follistatin (Fst) | |
920.6 | 286.0 | 754.3–1040.3 | 1683.0 | 1192.8 | 0.007∗∗ |
| MMP8 |
|
319.7 | 187.2 | 219.5–406.7 | 416.7 | 1319.90 | 0.026∗ |
| MMP-9 | |
156.4 | 126.2 | 110.8–237.0 | 244.8 | 1378.6 | 0.125 |
Bold type highlights analytes with median concentration in CSF from preterm infants that was outside the IQR of analyte concentration from controls; ∗p < 0.05, ∗∗p < 0.01. Pro-inflammatory function; anti-inflammatory function; supporting oligodendrocyte lineage responses and myelination; impairing oligodendrocyte lineage responses and myelination.