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. 2018 Sep 12;9:2069. doi: 10.3389/fimmu.2018.02069

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Copyright © 2018 Teskey, Cao, Islamoglu, Medina, Prasad, Prasad, Sathananthan, Fraix, Subbian, Zhong and Venketaraman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EMB and EMB+NAC effects on in vitro granulomas developed using immune cells from individuals with T2DM. Survival of M. tb inside EMB and EMB+NAC-treated granulomas (A) Hematoxylin and Eosin staining of RIF and RIF+NAC-treated granulomas from T2DM individuals (B), IFN-g levels at 15d post-infection (C), TNF-a levels at 15 days post-infection (D), and phagosome acidification at 15 days post-infection (E,F). ^**p < 0.005 when comparing samples treated with EMB only to those treated with EMB and NAC. ^*p < 0.05 when comparing samples treated with EMB+NAC to controls. ^**p < 0.005 when comparing samples treated with EMB+NAC to controls. ^#p < 0.05 when comparing samples treated with EMB+NAC to controls.