Figure 4.

Cell intrinsic mechanism by which Runx3 promotes intestinal group 1 ILC and NCR⁺ILC3 function against S. typhimurium infection. (A–E) Intestinal ILC1s from control mice and Runx3 KO mice were isolated and stimulated with IL12 and IL18 at 40 ng/mL for 1 hour before injection into NCG mice through the tail vein at days −1, 0, 1, and 5 after lavage with S. typhimurium. (A) The length of the colon, (B) statistical analysis of the colon length, (C) titre of S. typhimurium in the deiecta, (D) change of body weight, and (E) histology of the small intestine (left) and colon (right) were determined 9 days after infection. (mean ± SD of three samples in k and m; ^*P < 0.05 by Student's t-test). Data are from one experiment representative of two independent experiments with similar results in (A–E).