FIG. 4.

(A–L) (top) Magnitude of CD8⁺ T cell responses in subject 4 determined by ELISpot from stimulation with all determined minimal epitopes as well as all detected viral variant epitopes at more than one time point, in spot-forming units (SFU) per million cells. (bottom) Frequencies of each detected variant of the targeted peptide are noted in the table; dashes represent similarity to index sequence. *Represents a peptide that was tested in separate ELISpot assays. ND, not done.