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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Environ Toxicol Chem. 2017 Oct;36(10):2565–2573. doi: 10.1002/etc.3930

Figure 2.

Figure 2

A comparison of time points for erasure and reprogramming of the DNA methylome prior to fertilization and during embryogenesis in mammals and fish. The methylome is erased and reprogrammed in primordial germ cells at approximately the time of birth or hatching. Imprinting follows in mammals, but has not been established in fish. Following fertilization (F1) the methylome is again erased and reprogrammed between the zygote and blastocyststage in male and female mammals, but the paternal methylome appears to be maintained in fish at this stage. Adapted from Head, 2014 23.