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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: J Immunol. 2018 Aug 10;201(7):2004–2015. doi: 10.4049/jimmunol.1800070

Figure 2.

Figure 2.

IL-10 impairs late accumulation of effector myeloid cells in lungs of C. neoformans-infected mice. IL-10+/+ or IL-10−/− mice were infected with C. neoformans via intratracheal inoculation. At the indicated time points post infection, lungs were harvested from cohorts of mice and dispersed into single cell suspensions. Zero wpi designates uninfected mice. Cells were stained and analyzed by flow cytometry as described in Figure S1. The number of CD45+ cells (A), neutrophils (B), eosinophils (C), CD103+ conventional DCs (D), CD11b+ conventional DCs (E), monocyte-derived DCs (F), Ly6C+ monocytes (G), exudate macrophages (H) and alveolar macrophages (I) per mouse lung was calculated. Cumulative data from 3 (A-C) or 2 (D-I) independent experiments are presented as mean ± SEM of 4–12 mice. IL-10+/+ mice, black bars; IL-10−/− mice, white bars. ** P < 0.01, *** P < 0.001; t-test corrected for multiple comparisons using the Holm-Sidak method.