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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Semin Hematol. 2018 Mar 1;55(1):33–37. doi: 10.1053/j.seminhematol.2018.02.010

Figure 1. Distinguishing single CMMCs and BM MM cells from other cell types by single-cell RNA-sequencing.

Figure 1

Single CD138+CD45− MM cells were isolated either from the peripheral blood (PB Myeloma) or from the bone marrow (BM myeloma), and single CD19+ B lymphocytes (B cells) or CD45+ normal white blood cells (Normal cells) were isolated from the peripheral blood of two MM patients. CD138+CD45+ plasma cells (Plasma cells) were isolated from a healthy blood donor. Single cell whole transcriptome RNA sequencing was performed, and the gene expression of all single cells was visualized as two-dimensional t-SNE scatter plot. The symbol size represents the number of genes detected in each cell.