Table 2.
Quality of animal studies included in this analysis using SYRCLE's risk of bias tool for animal studies.
| Author( year) | (1) | (2) | (3) | (4) | (5) | (6) | (7) | (8) | (9) | (10) |
|---|---|---|---|---|---|---|---|---|---|---|
| Iwamoto (2000) |
Unclear | Unclear | Unclear | Unclear | Unclear | Yes | Unclear | Yes | No | Unclear |
| Michael (2001) |
Yes | Yes | Unclear | Unclear | Unclear | Yes | Unclear | Yes | Yes | Unclear |
| Brockmann (2009) |
Yes | Yes | Unclear | Unclear | Unclear | Yes | Unclear | Yes | Yes | Unclear |
| Fondevila (2011) |
Yes | Yes | Unclear | Unclear | Unclear | Yes | Unclear | Yes | Yes | Unclear |
| Monbaliu (2011) |
Unclear | Yes | Unclear | Unclear | Unclear | Yes | Unclear | Yes | Yes | Unclear |
| Fondevila (2012) |
Yes | Yes | Unclear | Unclear | Unclear | Yes | Unclear | Unclear | No | Unclear |
| Knaak (2014) |
Yes | Yes | Unclear | Unclear | Unclear | Yes | Unclear | No | No | Unclear |
| Fontes (2015) |
Yes | Yes | Unclear | Unclear | Unclear | Yes | Unclear | Yes | No | Unclear |
| Spetzler (2016) |
Yes | Yes | Unclear | Unclear | Unclear | Yes | Unclear | No | Yes | Unclear |
| Zhibin Zhang (2016) |
Yes | Yes | Unclear | Unclear | Unclear | Yes | Unclear | No | Yes | Unclear |
| Goldaracena (2016) |
Yes | Yes | Unclear | Unclear | Unclear | Yes | Unclear | No | Yes | Unclear |
Study quality items are (1) adequate sequence generation; (2) similar baseline characteristics for study groups; (3) allocation concealment present; (4) random housing utilised; (5) blinding of investigators; (6) all animals selected for outcome assessment; (7) blinding of outcome assessor(s); (8) incomplete outcome data addressed; (9) outcome reporting not selective; (10) other sources of bias present.