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. 2018 Sep 18;24:48. doi: 10.1186/s10020-018-0049-y

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Expression difference of H19 and ADIPOQ mRNA in paravertebral muscles of AIS patients is associated with curve severity and age at initiation. The relative expression difference of studied genes was calculated as the relative expression level of one gene in concave sided muscle minus that in convex sided. For (a), correlation analysis identified that the relative expression difference of H19 in AIS patients (n = 60) was positively correlated with the magnitude of spinal curve. For (b), the relative expression difference of ADIPOQ mRNA in AIS patients (n = 60) was negatively correlated with the magnitude of spinal curve. For (c), Heat map showed significant correlation of the expression difference of H19 and ADIPOQ mRNA in AIS patients (n = 60) with age at initiation of AIS