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. 2018 Mar 30;67(10):1845–1854. doi: 10.1136/gutjnl-2017-315201

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The kinetics of plasma human cytokines and cytolytic proteins after patient-derived xenograft (PDX) tumour engraftment in humice. PDX tumours were transplanted subcutaneously to humice (n=5) aged 8–10 weeks. Humice without tumour (n=5) were used as control. Plasma levels of human cytokines and cytolytic proteins at different time points are shown. (A) Interferon (IFN)-γ; (B) IL-2; (C) tumour necrosis factor (TNF)-α; (D) IL-4; (E) IL-6; (F) IL-10; (G) IL-12p40; (H) IL-18; (I) granzyme A; (J) granulysin. HCC, hepatocellular carcinoma.