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. 2018 Sep 18;20:211. doi: 10.1186/s13075-018-1711-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Plasma levels of (a) GAGs, (b) KS, and (c) HA in RA patients (n = 29) before anti-TNF-α therapy and in healthy subjects (n = 20). Data analyzed using Mann–Whitney U test. ^ap < 0.001, compared to healthy subjects. GAG glycosaminoglycan, HA hyaluronic acid, KS keratan sulfate, Max maximum, Min minimum, RA rheumatoid arthritis