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AG490 treatment inhibited TMEM119-induced MKN45 cell migration and invasion. Cell migration and invasion (A and B), and protein expression of STAT3, p-STAT3, VEGF, MMP2, and MMP9 (C–E) in MKN45 cells with recombined pLVX-Puro-TMEM119 vector transfection and/or AG490 (30 μM) treatment was measured by transwell and Western blot analysis, respectively. **P<0.01 compared with vector. ##P<0.01 compared with TMEM119.
