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The target of rapamycin (TOR) protein integrates nutrient responses to regulate growth. (A) In the presence of adequate nutrients, TOR is active, which represses recycling of cellular components via autophagy and promotes growth. (B) When nutrients are sensed as being limited either via insulin signaling, an increased AMP/ATP ratio, or artificially by exposure to the drug rapamycin, TOR is repressed which promotes autophagy and inhibits growth.
