Fig. 2.

The energetically-compromised genotype (simw⁵⁰¹); OreR was relatively resistant to the drug rapamycin. (A, B) The effect of rapamycin to increase development time was attenuated in (simw⁵⁰¹); OreR relative to control genotypes in both sexes. (C, D) (simw⁵⁰¹); OreR had similar survival to genetic controls in the absence of rapamycin, but had the highest survival in the presence of rapamycin in both sexes. Points are average trait values across seven to eight replicate vials with 95% CI for females (A, C) and males (B, D). Low survivorship of the Aut nuclear background accounts for the increase in variance and lack of error bars for development time at high rapamycin concentrations. Statistical results are in Supplementary Table S1 and the main text.