Table 2.
Percentage of trials with z < −1.96 and z < −2.576, for 10,000 simulated trials with 300 patients in each arm, for each of 30 conditions, with respective experimental and control median survival times of 4.2 and 3 and with loss to follow-up (LTFU) for some control patients.
|
y is uniform (w = 1) % rejection (one-tailed) at level of |
y is triangular (w = 2) % rejection (one-tailed) at level of |
||||
|---|---|---|---|---|---|
|
b, Weibull shape parameter |
Control patients, LTFU parameter |
0.025 | 0.005 | 0.025 | 0.005 |
| 0.8 | 0% | 69.28% | 45.24% | 69.17% | 44.63% |
| 5 | 55.58 | 32.29 | 52.68 | 28.99 | |
| 5 to 15 | 53.94 | 30.68 | 46.40 | 24.08 | |
| 10 | 41.36 | 20.72 | 36.21 | 17.07 | |
| 15 to 5 | 32.88 | 14.22 | 29.54 | 12.13 | |
| 1 (exponential distribution) | 0 | 87.50 | 69.60 | 87.41 | 69.59 |
| 5 | 79.25 | 58.00 | 77.08 | 54.59 | |
| 5 to 15 | 78.57 | 56.35 | 71.44 | 48.22 | |
| 10 | 67.31 | 44.22 | 62.35 | 38.14 | |
| 15 to 5 | 60.71 | 36.41 | 57.01 | 32.24 | |
| 1.25 | 0 | 97.38 | 91.49 | 97.86 | 91.16 |
| 5 | 95.25 | 85.54 | 94.36 | 83.30 | |
| 5 to 15 | 94.62 | 83.87 | 91.70 | 78.22 | |
| 10 | 91.20 | 76.97 | 87.93 | 71.44 | |
| 15 to 5 | 87.19 | 69.60 | 84.47 | 65.29 | |