Table 3.
Outcomes by quartile of MCP-1 and CKD status
| Non-CKD, N=2,971 | ||||
|---|---|---|---|---|
|
| ||||
| Variable | Quartile of MCP-1 (range, pg/mL) | |||
|
| ||||
| Q1 (1.7– 120.2) |
Q2 (120.3– 164.6) |
Q3 (164.7– 220.9) |
Q4 (221.0– 2011.0) |
|
| N=743 | N=742 | N=743 | N=743 | |
| Intermediate Outcomes | ||||
| CAC ≥100 Agatston units, N (%) | 27 (4.8) | 53 (8.8) | 53 (9.1) | 65 (10.9)a |
| LV mass/BSA, g/m2, median (IQR) | 79.0 (69.8, 91.3) | 79.8 (69.8, 92.2) | 79.7 (69.6, 92.0) | 79.7 (70.1, 92.8) |
| LVH, N (%) | 59 (10.2) | 52 (8.8) | 55 (9.3) | 58 (9.6) |
| Aortic PWV, m/s, median (IQR) | 4.1 (3.3, 5.4) | 4.1 (3.3, 5.5) | 4.2 (3.3, 5.6) | 4.5 (3.4, 5.9)a |
| Hard Outcomes | ||||
| All-cause death, N (%) | 33 (5.1) | 57 (8.4) | 53 (8.0) | 87 (12.8)a |
| ASCVD events, N (%) | 43 (6.7) | 36 (5.5) | 36 (5.7) | 51 (7.9) |
| Myocardial infarction, N (%) | 14 (2.2) | 12 (1.8) | 13 (2.0) | 20 (3.1) |
| Stroke, N (%) | 14 (2.2) | 8 (1.2) | 13 (2.0) | 18 (2.8) |
| CV revascularization, N (%) | 20 (3.1) | 21 (3.2) | 23 (3.6) | 27 (4.2) |
| CV death, N (%) | 7 (1.1) | 9 (1.4) | 3 (0.5) | 14 (2.2) |
|
| ||||
| CKD, N=286 | ||||
|
| ||||
| Variable | Quartile of MCP-1 (range, pg/mL) | |||
|
| ||||
| Q1 (48.9–142.9) | Q2 (143.0–191.9) | Q3 (192.0–270.9) | Q4 (271.0–2004.0) | |
| N=71 | N=72 | N=72 | N=71 | |
|
| ||||
| Intermediate Outcomes | ||||
| CAC ≥100 Agatston units, N (%) | 8 (14.8) | 12 (25.5) | 10 (17.9) | 15 (29.4) |
| LV mass/BSA, g/m2, median (IQR) | 96.0 (84.7, 108.1) | 87.8 (77.6, 106.6) | 86.1 (74.8, 107.6) | 93.4 (83.7, 126.5) |
| LVH, N (%) | 16 (32.0) | 15 (28.3) | 16 (28.6) | 22 (43.1) |
| Aortic PWV, m/s, median (IQR) | 5.4 (4.0, 6.7) | 5.5 (3.9, 6.8) | 5.1 (3.6, 7.0) | 5.6 (4.5, 8.4) |
| Hard Outcomes | ||||
| All-cause death, N (%) | 15 (24.2) | 24 (35.8) | 23 (34.3) | 35 (53.8)a |
| ASCVD events, N (%) | 14 (25.5) | 13 (22.8) | 17 (29.3) | 18 (35.3) |
| Myocardial infarction, N (%) | 5 (9.1) | 2 (3.5) | 6 (10.3) | 4 (7.8) |
| Stroke, N (%) | 3 (5.5) | 4 (7.0) | 7 (12.1) | 4 (7.8) |
| CV revascularization, N (%) | 9 (4.1) | 4 (7.0) | 5 (8.6) | 6 (11.8) |
| CV death, N (%) | 3 (5.5) | 5 (8.8) | 7 (12.1) | 9 (17.7)a |
ASCVD, atherosclerotic cardiovascular disease; BSA, body surface area; CAC, coronary artery calcification; CKD, chronic kidney disease; CV, cardiovascular; IQR, interquartile range; LV, left ventricular; LVH, left ventricular hypertrophy; MCP-1, monocyte chemoattractant protein-1
a
P<0.05 for trend