Table 4.

Associations of plasma MCP-1 with all-cause death and ASCVD events

Exposure Variable	All Participants HR (95% CI)	Non-CKD HR (95% CI)	CKD HR (95% CI)
All-cause death
Total cohort	N=3,257	N=2,971	N=286
Log MCP-1 unadjusted	1.9 (1.5, 2.2)	1.8 (1.5, 2.3)	1.9 (1.3, 2.8)
Log MCP-1 adjusteda	1.6 (1.3, 1.9)	1.6 (1.3, 2.0)	1.6 (1.1, 2.3)
Log MCP-1 adjusted + eGFRb	1.6 (1.3, 1.9)	1.6 (1.3, 2.0)	1.5 (1.0, 2.1)
Log MCP1 adjusted + hsCRPc	1.6 (1.3, 1.9)	1.6 (1.3, 2.0)	1.5 (1.0, 2.2)
Log MCP1 adjusted +ACRd	1.6 (1.3, 1.9)	1.6 (1.3, 2.0)	1.5 (1.1, 2.2)
No prior CVD	N=3,017	N=2,781	N=236
Log MCP-1 unadjusted	2.0 (1.6, 2.5)	2.0 (1.6, 2.5)	2.1 (1.3, 3.2)
Log MCP-1 adjusteda	1.8 (1.4, 2.2)	1.8 (1.4, 2.3)	1.7 (1.1, 2.7)
Log MCP-1 adjusted + eGFRb	1.8 (1.4, 2.2)	1.8 (1.4, 2.3)	1.6 (1.0, 2.5)
Log MCP1 adjusted + hsCRPc	1.8 (1.4, 2.2)	1.8 (1.4, 2.3)	1.7 (1.1, 2.6)
Log MCP1 adjusted + ACRd	1.8 (1.5, 2.2)	1.8 (1.4, 2.3)	1.7 (1.1, 1.7)
ASCVD events
Total cohorte	N=2,831	N=2,609	N=222
Log MCP-1 unadjusted	1.3 (1.0, 1.7)	1.2 (0.9, 1.6)	1.7 (1.0, 2.9)
Log MCP-1 adjusteda	1.0 (0.8, 1.4)	1.0 (0.8, 1.4)	1.2 (0.7, 2.0)
Log MCP-1 adjusted + eGFRb	1.0 (0.8, 1.3)	1.0 (0.8, 1.3)	1.0 (0.6, 1.7)
Log MCP1 adjusted + hsCRPc	1.0 (0.8, 1.3)	1.0 (0.7, 1.3)	1.2 (0.7, 2.0)
Log MCP1 adjusted + ACRd	1.0 (0.8, 1.3)	1.0 (0.7, 1.3)	1.1 (0.6, 1.9)
No prior CVD	N=2,605	N=2,420	N=185
Log MCP-1 unadjusted	1.2 (0.9, 1.6)	1.1 (0.8, 1.5)	1.5 (0.8, 2.8)
Log MCP-1 adjusteda	0.9 (0.7, 1.3)	0.9 (0.7, 1.3)	1.1 (0.5, 2.1)
Log MCP-1 adjusted + eGFRb	0.9 (0.7, 1.2)	0.9 (0.7, 1.3)	0.8 (0.4, 1.7)
Log MCP1 adjusted + hsCRPc	0.9 (0.7, 1.3)	0.9 (0.7, 1.3)	1.0 (0.5, 2.1)
Log MCP1 adjusted + ACRd	0.9 (0.7, 1.3)	0.9 (0.6, 1.2)	1.1 (0.5, 2.2)

ASCVD, atherosclerotic cardiovascular disease; CKD, chronic kidney disease; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; MCP-1, monocyte chemoattractant protein-1

^aAdjusted for traditional CV risk factors (age, sex, race, smoking, diabetes, hypertension, total and HDL cholesterol)

^bAdjusted for traditional CV risk factors and log transformed eGFR

^cAdjusted for traditional CV risk factors and log transformed hsCRP

^dAdjusted for traditional CV risk factors, log transformed log transformed ACR

^eIncludes 2,831 individuals in which adjudication for CV outcomes occurred through 2012.