. 2018 Sep 19;13(9):e0201308. doi: 10.1371/journal.pone.0201308

Table 3. The impact of individual components of FLI and HSI scores on the risk for prostate cancer by multivariable analyses.

Variables	Number	Outcome	Duration	IR	HR (95% CI)^a	P trend
BMI						< 0.001
< 18.5 Kg/m²	252248	1249	1300796	0.96	0.77 (0.72, 0.81)
18.5, 23.0 Kg/m²	3580475	16757	19134023	0.88	1 [Reference]
23.0, 25.0 Kg/m²	2823597	14659	15165239	0.97	1.16 (1.14, 1.19)
25.0, 30.0 Kg/m²	3472109	16474	18521411	0.89	1.20 (1.17, 1.23)
≥ 30.0 Kg/m²	388556	1145	2024372	0.57	1.26 (1.18, 1.33)
Abdominal obesity^b					< 0.001
No	8237809	35575	44118188	0.81	1 [Reference]
Yes	2279176	14709	12027653	1.22	1.15 (1.13, 1.17)
Dyslipidemia^c						< 0.001
No	6181691	28702	32986710	0.87	1 [Reference]
Yes	4212159	21142	22438762	0.94	1.07 (1.06, 1.09)
Diabetes						< 0.001
No	9425273	40424	50502501	0.80	1 [Reference]
yes	1091712	9860	5643340	1.75	1.05 (1.03, 1.07)
GGT^c						< 0.001
< 21 IU/L	2600002	13157	13932884	0.94	1 [Reference]
< 31 IU/L	2712295	14088	14590886	0.97	1.08 (1.05, 1.11)
< 50 IU/L	2572446	12709	13779962	0.92	1.13 (1.10, 1.16)
≥ 50 IU/L	2632242	10330	13842109	0.75	1.08 (1.05, 1.11)
ALT/AST^c						< 0.001
< 0.8	2643673	16950	13946366	1.22	1 [Reference]
0.8–1.0	2463015	13489	13163352	1.02	1.10 (1.08, 1.13)
< 1.3	2781073	12479	14906255	0.84	1.16 (1.13, 1.19)
≥ 1.3	2629224	7366	14129868	0.52	1.14 (1.11, 1.17)
ALT^d						< 0.001
< 18 IU/L	2812374	15345	14900042	1.03	1 [Reference]
< 24 IU/L	2535905	13787	13597829	1.01	1.08 (1.05, 1.10)
< 34 IU/L	2552043	12282	13688390	0.90	1.11 (1.08, 1.14)
≥ 34 IU/L	2616663	8870	13959580	0.64	1.10 (1.07, 1.13)
AST^d						0.236
< 20 IU/L	2526159	10557	13463044	0.78	1 [Reference]
< 24 IU/L	2651440	12648	14213703	0.89	1.00 (0.97, 1.02)
< 30 IU/L	2776167	14411	14891113	0.97	0.99 (0.96, 1.01)
≥ 30 IU/L	2563219	12668	13577982	0.93	0.99 (0.96, 1.01)
FLI^d						< 0.001
< 13.7	2629246	10733	14039989	0.76	1 [Reference]
< 29.4	2629246	14011	14123644	0.99	1.16 (1.13, 1.19)
< 52.7	2629247	14370	14087052	1.02	1.22 (1.19, 1.25)
≥ 52.7	2629246	11170	13895157	0.80	1.24 (1.21, 1.27)
HSI^d						< 0.001
< 29.1	2629307	13744	13942057	0.99	1 [Reference]
29.1–32.2	2629183	14142	14091688	1.00	1.18 (1.15, 1.21)
32.3–36.0	2629265	13279	14086812	0.94	1.24 (1.21, 1.27)
≥ 36.0	2629230	9119	14025284	0.65	1.27 (1.24, 1.31)

AST aspartate aminotransferase, ALT alanine transaminase, BMI body mass index, GGT gamma glutamyltransferase, FLI fatty liver index, HSI hepatic steatosis index, IR incidence rate, WC waist circumference.

^a Adjusted by age, smoking, drinking, exercise and income

^b Waist circumference ≥ 90cm for men

^c Triglyceride ≥ 150 mg/dL or user of lipid-lowering drug

^d The value was divided into quartile