TABLE I.
Number of Bone Tumor Cases by Behavior and Histological Type as Recorded in Hiroshima Tumor Tissue Registry, 1973-2012*
| Histological Group† | Benign | Intermediate | Malignant | ||||||
| ICD-O-3-M | Morphology | No. of Cases | ICD-O-3-M | Morphology | No. of Cases | ICD-O-3-M | Morphology | No. of Cases | |
| 1. Chondrogenic tumors | |||||||||
| 9210/0 | Osteochondroma | 1,057 | 9210/1 | Osteochondromatosis, NOS | 40 | 9220/3 | Chondrosarcoma, NOS; Conventional chondrosarcoma (grade 2, grade 3); Secondary chondrosarcoma | 124 | |
| 9220/0 | Chondroma, NOS; enchondroma; synovial chondromatosis | 952 | 9220/1 | Multiple chondromatosis | 3 | 9221/3 | Periosteal chondrosarcoma (juxtacortical chondrosarcoma) | 1 | |
| 9221/0 | Periosteal chondroma | 19 | 9231/3 | Myxoid chondrosarcoma | 3 | ||||
| 9230/0 | Chondroblastoma, NOS‡ | 23 | 9243/3 | Dedifferentiated chondrosarcoma | 2 | ||||
| 9241/0 | Chondromyxoid fibroma | 23 | 9240/3 | Mesenchymal chondrosarcoma | 4 | ||||
| 2. Osteogenic tumors | 9242/3 | Clear cell chondrosarcoma | 1 | ||||||
| 9180/0 | Osteoma, NOS | 254 | 9200/1 | Aggressive osteoblastoma | 1 | 9180/3 | Osteosarcoma | 176 | |
| 9191/0 | Osteoid osteoma | 83 | Osteoblastic osteosarcoma | ||||||
| 9200/0 | Osteoblastoma | 18 | 9181/3 | Chondroblastic osteosarcoma | 7 | ||||
| 9182/3 | Fibroblastic osteosarcoma | 4 | |||||||
| 9183/3 | Telangiectatic osteosarcoma | 6 | |||||||
| 9185/3 | Small cell osteosarcoma (round-cell osteosarcoma) | 1 | |||||||
| 9192/3 | Parosteal osteosarcoma | 7 | |||||||
| 3. Fibrogenic tumors | |||||||||
| 8810/0 | Fibroma, NOS | 13 | 8821/1 | Aggressive fibromatosis | 1 | 8810/3 | Fibrosarcoma | 4 | |
| 8823/0 | Desmoplastic fibroma | 2 | |||||||
| 4. Fibrohistiocytic tumors | |||||||||
| 8830/0 | Benign fibrous histiocytoma/non-ossifying fibroma (metaphyseal fibrous defect) | 10 | 8823/1 | Desmoplastic fibroma of bone | 7 | 8830/3 | Malignant fibrous histiocytoma | 33 | |
| 8831/0 | Histiocytoma, NOS | 2 | 8830/1 | Atypical fibrous histiocytoma | 3 | ||||
| 5. Hematopoietic tumors | |||||||||
| 6. Osteoclastic giant cell rich tumors | 9250/1 | Giant cell tumor of bone | 212 | 9250/3 | Malignancy in giant cell tumor of bone | 14 | |||
| 7. Notochordal tumors | |||||||||
| 9370/3 | Chordoma | 43 | |||||||
| 9371/3 | Chondroid chordoma | 4 | |||||||
| 8. Vascular tumors | |||||||||
| 9120/0 | Hemangioma, NOS | 16 | 9130/1 | Hemangioendothelioma, NOS | 2 | 9120/3 | Angiosarcoma | 7 | |
| 9121/0 | Cavernous hemangioma | 14 | 9133/1 | Epithelioid hemangioendothelioma, NOS | 1 | 9130/3 | Hemangioendothelioma, malignant | 1 | |
| 9122/0 | Venous hemangioma | 2 | 9136/1 | Spindle cell hemangioendothelioma | 1 | ||||
| 9131/0 | Capillary hemangioma | 6 | |||||||
| 9. Myogenic tumors | 8890/0 | Leiomyoma of bone | 1 | 8890/3 | Leiomyosarcoma of bone | 4 | |||
| 10. Lipogenic tumors | |||||||||
| 8850/0 | Lipoma of bone | 11 | |||||||
| 8861/0 | Angiolipoma, NOS | 1 | |||||||
| 11. Tumors of undefined neoplastic nature | |||||||||
| 8811/0 | Fibromyxoma | 2 | 9040/3 | Synovial sarcoma, NOS | 7 | ||||
| 8840/0 | Myxoma, NOS | 1 | 9041/3 | Synovial sarcoma, spindle cell | 1 | ||||
| 9262/0 | Ossifying fibroma | 28 | 9043/3 | Synovial sarcoma, biphasic | 1 | ||||
| 12. Miscellaneous tumors | |||||||||
| 8711/0 | Glomus tumor, NOS | 1 | 9150/1 | Hemangiopericytoma, NOS | 1 | 8800/3 | Sarcoma, NOS | 21 | |
| 8800/0 | Soft tissue tumor, benign | 1 | 8801/3 | Spindle cell sarcoma | 1 | ||||
| 8824/0 | Myofibroma | 1 | 9260/3 | Ewing sarcoma | 25 | ||||
| 9530/0 | Meningioma, NOS | 1 | 9261/3 | Adamantinoma of long bones | 4 | ||||
| 13. Other rare tumors | |||||||||
| 14. Unclassified tumors | |||||||||
| Total | 2,542 | 272 | 506 | ||||||
*
ICD-O-3-M = International Classification of Diseases for Oncology morphology code, NOS = not otherwise specified.
†
The histological group was based on the WHO 2013 classification.
‡
Chondroblastoma is regarded as demonstrating intermediate behavior according to the WHO 2013 classification; however, it is included as a benign tumor here because its ICD-O-3 behavior code is 0.