Fig 4. Individual associations of RoCA sectors with the biochemical domains of the studied viral proteins.
The sectors are colored according to the scheme in Fig 3A. The area of each bubble reflects the statistical significance of the associated result, measured as −1/log10 P, where P is the P-value computed using Fisher’s exact test, and the black circles indicate the conventional threshold of statistical significance, P = 0.05; any P-value lower than that (bubble inside the black circle) is considered statistically significant. The star symbols indicate those RoCA sectors with unknown biochemical significance. Note that the involved structural interfaces were defined based on a contact distance of less than d = 7Å between the alpha-carbon atoms. Similar qualitative results are obtained for d = 8Å or d = 9Å (S2 Fig).