Table. Screening Protocol for Male BRCA Mutation Carriers and Number of Previous and New Malignant Abnormalities Identified in a Cohort of 196 Men^a.

Organ	Screening Test	Frequency	Previous Malignant Abnormalities, No.	New Malignant Abnormalities, No.
Prostate	PSA	1 Year	4	9
	DRE	1 Year
	MRI	Performed at initial screening and before prostate biopsy in men aged 40 to 70 years
Breast	Clinical breast examination	1 Year	2	0
	Mammogram	Initial mammogram at age 40 years; frequency of subsequent testing determined by initial findings and patient age
Pancreas	CA-19-9	1 Year	2	2
	Abdominal ultrasound	1 Year
Colorectal	CEA	1 Year	2	0
	Colonoscopy	Every 5 years; screening is initiated at 45 years
Skin	Dermatologist examination	1 Year; screening is initiated on enrollment disregarding patient age	11	1

Abbreviations: DRE, digital rectal examination; MRI, magnetic resonance imaging; PSA, prostate-specific antigen.

^aThe screening protocol for prostate and breast cancer is based on the National Comprehensive Cancer Network Genetic/Familial High-Risk Assessment: Breast and Ovarian (version 1.2014) with the addition of prostatic MRI. Screening for pancreatic, colorectal and skin cancer were based on specific society recommendations with the aim of minimizing the use of radiation and invasive studies; screening was initiated at age 40 years, except for where noted otherwise.