| PTMA |
-2.80 |
Thymosin A1: involved in chromatin remodeling, DNA replication, has anti-apoptotic function as well |
| UQCRFS1 |
-2.60 |
Ubiquitinol Cyt C reductase: iron sulfur polypeptide in mitochondrial respiratory chain, ATP synthesis |
| TAF1D |
-2.41 |
RNA POL1 TATA-box binding factor, rRNA synthesis |
| RAD17 |
-2.22 |
Required for cell cycle arrest during DDR |
| OXR1 |
-1.94 |
Oxidative stress resistance, transcriptional stress network regulator |
| SUMO2 |
-1.81 |
Sumoylation protein, important in DDR pathway function |
| TXN |
-1.52 |
Thioredoxin: redox signaling, reduce oxidative stress during stress responses, cell survival during stress |
| MIS12 |
-1.36 |
Kinetochore complex protein, promotes proper mitotic chromosome alignment |
| CEP70 |
-0.93 |
Regulates microtubule assembly, promotes resistance to microtubule assembly drugs |
| FGF9 |
-1.14 |
Stimulates cell proliferation, cell survival |
| CENPH |
-1.12 |
Kinetochore and centromere protein, involved in sister chromatid separation during DNA replication |
| CETN3 |
-1.00 |
Centrin-3: chromosome duplication and separation |
| ESCO-1 |
-1.00 |
N-acetyl transferase: chromatid cohesion and DNA replication |
| RAD51C |
-1.00 |
dsDNA break repair |
| CDKN2 |
-1.00 |
CDK4 inhibitor, prevents unauthorized cell cycle progression, block cell cycling during DNA damage |
| ESCO1 |
-1.00 |
Sister chromatid adhesion |
| CASC1 |
-1.00 |
Cancer susceptibility |
| CDK7 |
-0.95 |
Promotes G2-M transition |
| POLR1D |
-0.95 |
Required for rRNA synthesis |
| POLQ |
-0.92 |
Essential for DNA repair during DNA damage and restricted homologous recombination repair pathway |
| CIRBP1 |
-0.94 |
Cold inducible RNA binding protein, protects against DNA damage during stress |
| POLB |
-0.93 |
DNA base-excision repair, DDR |
| FBXW7 |
-0.92 |
F-box ubiquitination protein. Cyclin E target. Protective against ovarian cancer. |
| RALB |
-0.88 |
Multifunctional GTPase, involved in signaling, cell proliferation activation |
