Table 1. Baseline Characteristics and Neuroimaging Findings by Status of Cerebral Microbleeds (CMBs).
| Variable | No CMBs (n = 47) | CMBs (n = 120) |
|---|---|---|
| Demographic and Clinical Characteristics | ||
| Male, No. (%) | 25 (53.2) | 73 (60.8) |
| Age, mean (SD), y | 61.6 (13.4) | 62.0 (13.2) |
| Race/ethnicity, No. (%) | ||
| White | 21 (44.7) | 31 (25.8) |
| Black | 5 (10.6) | 22 (18.3) |
| Asian | 21 (44.7) | 63 (52.5) |
| Other | 0 | 4 (3.3) |
| Smoking, No./total No. (%) | 16/44 (36.4) | 55/110 (50.0) |
| Cocaine use, No./total No. (%) | 2/46 (4.3) | 8/105 (7.6) |
| Hypertension, No./total No. (%) | 33/47 (70.2) | 92/118 (78.0) |
| SBP at initial presentation, mean (SD), mm Hg | 197.2 (27.1) | 198.9 (27.3) |
| DBP at initial presentation, mean (SD), mm Hg | 109.3 (22.2) | 111.5 (19.7)a |
| Prior stroke/transient ischemic attack, No. (%) | 8 (17.0) | 18 (15.0) |
| Congestive heart failure, No. (%) | 2 (4.3) | 5 (4.2) |
| Atrial fibrillation, No. (%) | 0 | 2 (1.7) |
| Diabetes, No./total No. (%) | 8/47 (17.0) | 23/118 (19.5) |
| Ischemic heart disease, No. (%)b | 2 (4.3) | 2 (1.7) |
| Hyperlipidemia, No./total No. (%) | 14/46 (30.4) | 31/116 (26.7) |
| Peripheral vascular disease, No./total No. (%) | 0/46 | 3/120 (2.5) |
| Time from onset to baseline computed tomography, median (IQR), min | 79 (64-108) | 80 (58-121) |
| Laboratory Values | ||
| Total white blood cell count, mean (SD), /μL | 7800 (2700) | 7500 (2400) |
| Platelet count, mean (SD), ×103/μL | 211.4 (47.4) | 215.1 (57.4) |
| Hemoglobin, mean (SD), g/dL | 14.3 (1.4) | 14.3 (1.7) |
| Hematocrit, mean (SD), % | 42.4 (3.7) | 42.2 (4.9) |
| Serum glucose, median (IQR), mg/dL | 125 (106-156) | 119 (105-143) |
| Serum creatinine, median (IQR), mg/dL | 0.8 (0.7-1.1) | 0.9 (0.7-1.2) |
| Creatinine >1.5 mg/dL, No. (%) | 1 (2.1) | 17 (14.2) |
| Neurological Scales | ||
| Baseline Glasgow Coma Scale score, No. (%) | ||
| 3-11 | 5 (10.6) | 12 (10.0) |
| 12-14 | 11 (23.4) | 34 (28.3) |
| 15 | 31 (66.0) | 74 (61.7) |
| Baseline NIHSS score, median (IQR) | 9 (6-16) | 9 (4-15) |
| Assigned Treatment Group, No. (%) | ||
| Intensive treatment | 27 (57.4) | 55 (45.8) |
Abbreviations: DBP, diastolic blood pressure; IQR, interquartile range; NIHSS, National Institutes of Health Stroke Scale; SBP, systolic blood pressure.
SI conversion factors: To convert white blood cell count to ×109/L, multiply by 0.001; platelet count to ×109/L, multiply by 1.0; hemoglobin level to grams per liter, multiply by 10.0; hematocrit to proportion of 1.0, multiply by 0.01; glucose level to millimoles per liter, multiply by 0.0555; creatinine level to micromoles per liter, multiply by 88.4.
a
Data were missing for 1 patient in the CMB group.
b
Previous coronary artery bypass grafting, myocardial infarction within 3 months, angina pectoris, or percutaneous transluminal coronary angioplasty.