Table 1. Proportion of the Population With Consanguineous Parents by Level of Consanguinity and Demographic Characteristics.
| Variable | All, No. (%) (N = 363 960) |
% | P Valuea | |||
|---|---|---|---|---|---|---|
| Not Related (n = 344 183) |
First Cousins (n = 260) |
Second Cousins (n = 349) |
Not Known (n = 19 168) |
|||
| Sex | ||||||
| Male | 191 102 (52.5) | 52.5 | 53.9 | 51.3 | 51.7 | .82 |
| Female | 172 858 (47.5) | 47.5 | 46.1 | 48.7 | 48.3 | |
| Age, y | ||||||
| 26-29 | 97 399 (26.8) | 27.1 | 43.1 | 39.8 | 21.1 | <.01 |
| 30-33 | 95 663 (26.3) | 26.4 | 18.1 | 21.2 | 24.3 | |
| 34-37 | 87 065 (23.9) | 23.0 | 22.3 | 17.5 | 40.5 | |
| 38-41 | 83 833 (23.0) | 23.5 | 16.5 | 21.5 | 14.1 | |
| SGA | ||||||
| No | 342 412 (94.1) | 94.1 | 92.3 | 93.7 | 93.8 | .45 |
| Yes | 21 548 (5.9) | 5.9 | 7.7 | 6.3 | 6.2 | |
| Delivery methodb | ||||||
| Vaginal | 290 841 (79.9) | 80.0 | 82.3 | 78.2 | 79.0 | .46 |
| Vaginal assisted (ie, forceps, vacuum) and cesarean delivery | 73 119 (20.1) | 20.0 | 17.7 | 21.8 | 21.0 | |
| Parity | ||||||
| Firstborn | 96 685 (26.6) | 26.5 | 20.0 | 27.8 | 27.9 | <.01 |
| 1 | 105 750 (29.1) | 29.3 | 23.5 | 22.6 | 25.8 | |
| 2 | 64 794 (17.8) | 17.9 | 12.7 | 16.1 | 16.0 | |
| ≥3 | 70 968 (19.5) | 19.5 | 33.5 | 22.4 | 19.7 | |
| Unknown | 25 763 (7.1) | 6.9 | 10.4 | 11.2 | 10.6 | |
| Mother’s age, mean, y | 27.7 | 27.7 | 27.0 | 27.0 | 27.3 | .08 |
| Father’s age, mean, y | 30.2 | 30.1 | 37.4 | 35.2 | 31.6 | <.01 |
| Deprivation at birth | ||||||
| Not deprived | 200 238 (55.0) | 55.4 | 41.9 | 58.7 | 48.0 | <.01 |
| Deprived | 156 797 (43.1) | 42.7 | 53.1 | 38.4 | 49.8 | |
| Not known | 6925 (1.9) | 1.9 | 5.0 | 2.9 | 2.2 | |
| Urbanicity at birth | ||||||
| Urban | 144 647 (39.7) | 39.8 | 31.2 | 22.4 | 39.2 | <.01 |
| Rural | 212 369 (58.3) | 58.3 | 63.9 | 74.8 | 58.6 | |
| Not known | 6944 (1.9) | 1.9 | 5.0 | 2.9 | 2.2 | |
| Common mood medication use | ||||||
| No | 269 201 (74.0) | 74.0 | 64.2 | 68.8 | 73.2 | <.01 |
| Yes | 94 759 (26.0) | 26.0 | 35.8 | 31.2 | 26.8 | |
| Antipsychotic medication use | ||||||
| No | 354 156 (97.3) | 97.3 | 91.5 | 95.7 | 96.9 | <.01 |
| Yes | 9804 (2.7) | 2.7 | 8.5 | 4.3 | 3.1 | |
Abbreviation: SGA, small for gestational age.
a
P values represent χ2 test for difference between not related and related populations only (excluding the “Not Known” column).
b
Delivery method summarized as “Natural” or “Other” owing to small cell counts.