Table 1.
NKG2D ligands expression in human cancers
| Tumor type | Ligands identified | Known regulation |
|---|---|---|
| Carcinoma | ||
| • Ovarian | MICA/B, ULBP2 | Shedding |
| • Cervical cancer | MICA | Shedding |
| • Breast | MICA/B HER2/3, | Shedding |
| • Lung | MICA/B | Shedding |
| • Hepatocellular | MICA/B | Viral, retinoic acid |
| • Colon | MICA | Shedding |
| • Renel | MICA, MICB | ? |
| • Prostate | MICA (Hi), ULBP (lo) | Shedding |
| • Pancreatic | MICA/B | ? |
| • Head and neck cancer |
MICA/B | Shedding |
| Leukemia | MICA/B | Methylation |
| Lymphoma | MICA, ULBPS | Shedding |
| Multiple myeloma | MICA | Shedding |
| Melanoma | MICA, ULBP-2 | Shedding |
| Giloma | MICA/B,ULBP1–3 | TGF-b |
| OsteoSarcoma | MICA | ? |
| Neuroblastoma | MICA, ULBP-2 | Releasing soluble form |