Table 2. Tumor CNA burden is associated with recurrence and overall survival independent of disease stage in multiple cancer types.
| Cohort | Model | Disease free Time | Overall Survival | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases | HR | 95% CI | P | Cases | HR | 95% CI | P | ||
| Prostate cancer TCGA | Tumor CNA burden, per 5% tumor CNA burden, univariate | 280 | 1.27 | 1.13, 1.42 | <0.0001 | Insufficient events |
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| Tumor CNA burden, per 5% tumor CNA burden, adjusted for Gleason grade and mutation burden | 279 | 1.18 | 1.03, 1.35 | 0.015 | |||||
| Tumor CNA burden, per 5% tumor CNA burden, adjusted for purity (ABSOLUTE)* | 243 | 1.22 | 1.07, 1.40 | 0.003 | |||||
| Tumor CNA burden, per 5% tumor CNA burden, adjusted for ploidy | 243 | 1.32 | 1.11, 1.56 | 0.002 | |||||
| Breast cancer TCGA | Tumor CNA burden, per 5% tumor CNA burden, univariate | 709 | 1.07 | 1.01, 1.14 | 0.028 | 794 | 1.08 | 1.03, 1.13 | 0.0005 |
| Tumor CNA burden, per 5% tumor CNA burden, Multivariable, adjusted for disease stage | 695 | 1.07 | 1.00, 1.14 | 0.049 | 777 | 1.08 | 1.03, 1.13 | 0.002 | |
| Endometrial Cancer TCGA | Tumor CNA burden, per 5% tumor CNA burden, univariate | 496 | 1.10 | 1.06, 1.14 | <0.0001 | 536 | 1.13 | 1.08, 1.17 | <0.0001 |
| Tumor CNA burden, per 5% tumor CNA burden, multivariable, adjusted for disease stage | 496 | 1.08 | 1.04, 1.13 | <0.0001 | 536 | 1.10 | 1.05, 1.15 | <0.0001 | |
| Renal clear cell cancer TCGA | Tumor CNA burden, per 5% tumor CNA burden, univariate | 425 | 1.05 | 1.01, 1.09 | 0.028 | 525 | 1.02 | 0.98, 1.06 | NS (0.4) |
| Tumor CNA burden, per 5% tumor CNA burden, multivariable, adjusted for disease stage | 423 | 1.05 | 1.00, 1.11 | 0.035 | 522 | 1.01 | 0.97, 1.06 | NS (0.7) | |
| Thyroid cancer TCGA | Tumor CNA burden, per 5% tumor CNA burden, univariate | 483 | 1.17 | 1.01, 1.35 | 0.033 | 497 | 1.30 | 1.04, 1.63 | 0.021 |
| Tumor CNA burden, per 5% tumor CNA burden, multivariable, adjusted for disease stage | 481 | 1.18 | 1.00, 1.39 | 0.048 | Insufficient events | ||||
| Colorectal cancer TCGA | Tumor CNA burden, per 5% tumor CNA burden, univariate | 512 | 1.05 | 1.00, 1.11 | 0.037 | 587 | 1.06 | 1.01, 1.12 | 0.012 |
| Tumor CNA burden, per 5% tumor CNA burden, multivariable, adjusted for disease stage | 496 | 1.03 | 0.98, 1.09 | NS (0.3) | 567 | 1.03 | 0.97, 1.09 | NS (0.3) | |
| Tumor CNA burden, per 5% tumor CNA burden, multivariable, adjusted for tumor stage | 511 | 1.06 | 1.01, 1.12 | 0.028 | 585 | 1.07 | 1.02, 1.13 | 0.009 | |
*Result differed with similar adjustment in IMPACT prostate cancer cohort utilizing FACETS, see Supplementary file 3.