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. 2018 Sep 19;8:14046. doi: 10.1038/s41598-018-32386-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Siglec-1 dependent capture of human reticulocyte-derived exosomes by mature dendritic cells. (A) Flow cytometry analysis of HuRex_DiI capture by mDCs. (B) Confocal microscopy co-localization of HuRex_DiI (in red) and VLP_HIV-Gag-eGFP (in green) in mDCs (nuclei stained with DAPI). Top: z-plane showing fluorescence and bright field (scale bar 5 μm); Bottom: 3D reconstruction of z-planes (reference scale unit 2,48 μm). (C) Inhibition of HuRex_DiI capture by mDCs by blocking of Siglec-1 with α-Siglec-1 mAb. mDCs not treated with antibodies nor with HuRex_DiI were incubated in parallel (C neg). Data show mean values and SD from 2 donors. T-test P < 0.05.