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. 2018 Sep 19;8:14061. doi: 10.1038/s41598-018-32250-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Boxplots showing comparisons of plaque number and surface area between Tg FUS and Tg CTL animals. Top: Representative maximum projection images of hippocampi in Tg FUS (left) and Tg CTL (right) animals (magenta = NeuN, cyan = 6F3D). Bottom: Plaque number (a) in Tg FUS mice decreased significantly by 27 ± 7% compared to Tg CTL littermates (300 ± 30 and 420 ± 20, respectively, p = 0.006). Maximum cross-sectional area of plaques (b) in Tg FUS mice was comparable to that observed in Tg CTL littermates (350 ± 20 and 310 ± 20 µm², respectively, p = 0.24). Plaque surface area (c) in Tg FUS mice decreased significantly by 40 ± 10% compared to Tg CTL littermates (9270 ± 660 and 15400 ± 1360 µm², respectively, p = 0.004). Data tables can be found in Supplementary Table S13. Error bars show mean ± SD, n = 5 for each group, **p ≤ 0.01.