Table 1. The Effects of Antidiabetic Therapies on Fracture Risk.
Antidiabetic therapies | Fracture risk |
---|---|
Metformin | ↓→ |
Sulphonylureas | ↑↓→ |
Glitazones | ↑ |
DPP-4 inhibitors | ↓→ |
GLP-1 RA | → |
SGLT-2 inhibitors | → |
Insulin | ↑↓→ |
Increased fracture risk (↑), decreased fracture risk (↓), neutral effects on fracture risk (→).
DPP-4, dipeptidylpeptidase 4; GLP-1 RA, glucagon-like peptide 1 receptor agonist; SGLT-2, sodium-glucose co-transporter 2.