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. 2018 Sep 18;33(3):339–351. doi: 10.3803/EnM.2018.33.3.339

Table 1. The Effects of Antidiabetic Therapies on Fracture Risk.

Antidiabetic therapies Fracture risk
Metformin ↓→
Sulphonylureas ↑↓→
Glitazones
DPP-4 inhibitors ↓→
GLP-1 RA
SGLT-2 inhibitors
Insulin ↑↓→

Increased fracture risk (↑), decreased fracture risk (↓), neutral effects on fracture risk (→).

DPP-4, dipeptidylpeptidase 4; GLP-1 RA, glucagon-like peptide 1 receptor agonist; SGLT-2, sodium-glucose co-transporter 2.