Table 1. Demographic and Baseline Characteristics of Non-alcoholic Fatty Liver Disease Patients with T2DM.
| Characteristic | Metformin+DPP4i (n=52) | Metformin+dapagliflozin (n=50) | P value |
|---|---|---|---|
| Age, yr | 56.6±7.4 | 50.7±10.2 | 0.001 |
| Sex | 0.441 | ||
| Male | 34 (65.4) | 31 (62.0) | |
| Female | 18 (34.6) | 19 (38.0) | |
| Body weight, kg | 73.7±12.8 | 79.8±14.6 | 0.028 |
| Height, cm | 166.4±7.9 | 166.8±9.4 | 0.804 |
| BMI, kg/m2 | 26.47±3.35 | 28.56±3.92 | 0.005 |
| Duration of T2DM, yr | 5.5±5.3 | 4.0±4.5 | 0.540 |
| HbA1c, % | 7.4±1.5 | 8.3±1.7 | 0.005 |
| FBS, mg/dL | 133.6±33.1 | 175.1±57.3 | <0.001 |
| HOMA-IR | 2.6±1.8 | 6.4±2.3 | 0.003 |
| AST, U/L | 35.6±9.6 | 36.3±11.2 | 0.740 |
| ALT, U/L | 49.6±10.4 | 51.9±14.7 | 0.362 |
| Total cholesterol, mg/dL | 160.9±32.5 | 186.2±43.8 | 0.002 |
| LDL-C, mg/dL | 93.3±27.4 | 102.3±40.7 | 0.205 |
| HDL-C, mg/dL | 43.3±10.6 | 48.5±16.1 | 0.071 |
| Triglycerides, mg/dL | 155.7±67.6 | 217.9±131.3 | 0.005 |
| Hypertension | 32 (61.5) | 34 (68.0) | 0.040 |
| Estimated GFRa, mL/min/1.73 m2 | 70.5±10.8 | 75.4±14.1 | 0.055 |
Values are expressed as mean±SD or number (%).
T2DM, type 2 diabetes mellitus; DPP4i, dipeptidyl peptidase-4 inhibitor; BMI, body mass index; HbA1c, glycated hemoglobin; FBS, fasting blood sugar; HOMA-IR, homeostatic model assessment of insulin resistance; AST, aspartate aminotransferase; ALT, alanine aminotransferase; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; GFR, glomerular filtration rate.
aCalculation of estimated GFR based upon the Modification of Diet in Renal Disease formula; estimated GFR (mL/min/1.73 m2)=186×serum creatinine (mg/dL)−1.154×(age)−0.203×(0.742, if female)×(1.21, if black).