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. 2018 Sep 25;68(675):e673–e681. doi: 10.3399/bjgp18X699053

Table 2.

Changes in antidepressant medication taken during follow-up

Baseline–3 months (n = 219) 3–6 months (n = 207) 6–9 months (n = 191) 9–12 months (n = 181)
No longer taking antidepressants (already stopped + new stops) 8 14 11 14

Still taking antidepressants 211 191 175 165

Re-started taking antidepressants 0 2 5 2

1st time point 2nd time point Baseline–3 months (n = 203)a 3–6 months (n = 181)a 6–9 months (n = 170)a 9–12 months (n = 161)a

Monotherapy Continued on same drug 176 156 142 131
Same dose 147 130 113 103
  Increased dose 17 14 15 17
  Reduced dose 12 12 14 11

Switched antidepressant 5 2 3 6
  Within class 1 1 1 2
  Between class 4 1 2 4

Combination therapy/augmented antidepressant 5 5 4 7
  Second antidepressantb 5 5 4 7
  Non-antidepressant augmenter 0 0 0 0

Combination therapy Continued on combination therapyb 14 15 15 14
  Same combination of drugsc 14 15 14 13
  Different combination 0 0 1 1

Change to monotherapy 3 3 6 3

Missing information on type and/or dose of antidepressant 8 10 5 4
a

Number of patients with data on type and dose of antidepressant medication among those still taking antidepressants.

b

Includes combinations where the second antidepressant is low-dose (<75 mg) amitriptyline.

c

Dose of medication may have changed.