Table 2.
Changes in antidepressant medication taken during follow-up
Baseline–3 months (n = 219) | 3–6 months (n = 207) | 6–9 months (n = 191) | 9–12 months (n = 181) | ||
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No longer taking antidepressants (already stopped + new stops) | 8 | 14 | 11 | 14 | |
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Still taking antidepressants | 211 | 191 | 175 | 165 | |
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Re-started taking antidepressants | 0 | 2 | 5 | 2 | |
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1st time point | 2nd time point | Baseline–3 months (n = 203)a | 3–6 months (n = 181)a | 6–9 months (n = 170)a | 9–12 months (n = 161)a |
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Monotherapy | Continued on same drug | 176 | 156 | 142 | 131 |
Same dose | 147 | 130 | 113 | 103 | |
Increased dose | 17 | 14 | 15 | 17 | |
Reduced dose | 12 | 12 | 14 | 11 | |
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Switched antidepressant | 5 | 2 | 3 | 6 | |
Within class | 1 | 1 | 1 | 2 | |
Between class | 4 | 1 | 2 | 4 | |
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Combination therapy/augmented antidepressant | 5 | 5 | 4 | 7 | |
Second antidepressantb | 5 | 5 | 4 | 7 | |
Non-antidepressant augmenter | 0 | 0 | 0 | 0 | |
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Combination therapy | Continued on combination therapyb | 14 | 15 | 15 | 14 |
Same combination of drugsc | 14 | 15 | 14 | 13 | |
Different combination | 0 | 0 | 1 | 1 | |
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Change to monotherapy | 3 | 3 | 6 | 3 | |
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Missing information on type and/or dose of antidepressant | 8 | 10 | 5 | 4 |
Number of patients with data on type and dose of antidepressant medication among those still taking antidepressants.
Includes combinations where the second antidepressant is low-dose (<75 mg) amitriptyline.
Dose of medication may have changed.