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. 2018 Sep 13;11:328. doi: 10.3389/fnmol.2018.00328

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Copyright © 2018 Louros, Caldeira and Carvalho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A model for the role of stargazin dephosphorylation in scaling down. At postsynaptic sites, PSD-95 binds to stargazin, which is highly phosphorylated at the C-terminus, trapping AMPA receptors at synapses. During prolonged periods of increased synaptic activity, PP1 is activated and stargazin is dephosphorylated resulting in increased lateral diffusion of stargazin and AMPA receptors at synapses (A). AMPA receptors are endocytosed via clathrin/AP-2-independent or–dependent mechanisms (B) and directed to late endosomes through interaction with AP-3A (C).