Table 1.

Comparison of the structure and relationships of dense core vesicles to those of synaptic vesicles.

	Dense core vesicles		Synaptic vesicles
	Mean ± SD	n	Mean ± SD	n	Reference	p-Value	Statistic Test
# of rib connections per vesicle	4.4 ± 0.54	5	3.9 ± 0.6	20	Szule et al., 2012 Harlow et al., 2013	0.08	Mann–Whitney
			4.2 ± 0.4	12		0.35
# of spar connections per vesicle	2.2 ± 0.45	5	2.2 ± 0.5	20	Szule et al., 2012 Harlow et al., 2013	0.99	Mann–Whitney
			2.0 ± 0.4	12		0.43
# of boom connections per vesicle	6.0 ± 0.71	5	5.0 ± 2.0	20	Szule et al., 2012 Harlow et al., 2013	0.24	Mann–Whitney
			7.0 ± 0.9	12		0.051
# of pin connections per vesicle	5.0 ± 1.4	4	4.1 ± 0.7	12	Szule et al., 2012 Harlow et al., 2013	0.16	Mann–Whitney
			3.9 ± 1.3	12		0.15
# of non-AZM connections per vesicle	12.0 ± 2.6	3	8.5 ± 1.8	10	Harlow et al., 2013	0.04∗	Mann–Whitney
Rib-vesicle distance to PM (nm)	10.5 ± 2.8	4	7.7 ± 3.3	20	Szule et al., 2012 Jung et al., 2016	0.13	Mann–Whitney
			12.1 ± 2.5	101		0.22
Rib-vesicle distance to spar-vesicle (nm)	8.7 ± 2.7	5	10.3 ± 4.4	20	Szule et al., 2012	0.32	Mann–Whitney
Rib-vesicle Distance to boom-vesicle (nm)	27.0 ± 5.3	5	24.2 ± 6.6	20	Szule et al., 2012	0.23	Mann–Whitney
Total surface area of vesicle (nm2)	27950 ± 4809	3	8298 ± 1113	12	Harlow et al., 2013	0.012∗	Mann–Whitney
AZM binding domain-diameter (nm)	40.9 ± 9.3	5	34.9 ± 4.2	12	Harlow et al., 2013	0.10	Mann–Whitney
AZM binding domain-area (nm2)	1508 ± 818	5	1135 ± 312	12	Harlow et al., 2013	0.43	Mann–Whitney
% surface area of AZM binding domain	6.0 ± 3.4	3	13.7 ± 3.6	12	Harlow et al., 2013	0.017∗	Mann–Whitney
Vesicle fusion domain area (nm2)	2182 ± 1477	4	1426 ± 279	12	Szule et al., 2012	0.43	Mann–Whitney
% surface area of fusion domain	11.1 ± 7.3	3	17.2 ± 3.3	12	Szule et al., 2012	0.22	Mann–Whitney
Vesicle-PM contact area (nm2)	310 ± 180	6	330 ± 150	101	Jung et al., 2016	0.71	Mann–Whitney

SD, standard deviation; PM, presynaptic membrane; ^∗ indicates that the p-value < 0.05.