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. 2018 Sep 13;9:1029. doi: 10.3389/fphar.2018.01029

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Copyright © 2018 Zhang, Li, Liu, Chen, Chen, Tan, Ma and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathway analysis of the differential metabolites. (A) Pathway analysis of 40 differential metabolites. The size and color of each circle was based on pathway impact value and p-value, respectively. (B) Metabolic pathways were visualized by means of cytoscape software. The differential metabolites in our study were represented by red hexagons. Hexagons with green lines mean that the alteration of the biomarkers in CKD had statistical significance. The size of hexagons indicated the FC of the corresponding metabolite in CKD in relative to controls. In addition, pink hexagons indicated metabolites participating in the metabolic pathway but not been detected in our study. Diamonds mean that the metabolites convert to the products by the reactions.