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. Author manuscript; available in PMC: 2019 Sep 19.
Published in final edited form as: ACS Chem Neurosci. 2018 May 8;9(9):2274–2285. doi: 10.1021/acschemneuro.8b00131

Figure 1.

Figure 1

Structures of reported M1 PAMs with varying degrees of M1 PAM potency, varying degrees of M1 ago-PAM activity in recombinant cell lines and native tissues, and a diverse range of cholinergic AEs.