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. 2018 Sep 13;9:1996. doi: 10.3389/fimmu.2018.01996

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Copyright © 2018 Pal Singh, de Bruijn, de Almeida, Meijers, Nitschke, Langerak, Pillai, Stadhouders and Hendriks.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A unique set of genes and pathways is upregulated in V_H11 vs. non-V_H11 CLL in IgH.TEμ mice. (A) Volcano plot showing P-values and fold changes in gene expression levels comparing V_H11 and non-V_H11 CLL from IgH.TEμ mice. Genes upregulated in non-V_H11 CLL are indicated in red; genes upregulated in V_H11 CLL in blue. Only significantly different genes (Benjamini-Hochberg adjusted p-value < 0.05) are shown. Genes indicated represent a subset of the validation gene set analyzed in a larger CLL (see Figure 7). (B) Oncogenic hallmark signatures enriched among differentially expressed genes in V_H11 (n = 3) vs. non-V_H11 (n = 3) CLL from IgH.TEμ mice.