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. 2018 Sep 13;9:2079. doi: 10.3389/fimmu.2018.02079

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Copyright © 2018 Chen, Huang, Fu, Li, Ran, He, Jiang, Li, Liu, Xie, Liu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GPR109A regulates the gut microbiota of mice. (A) Principal coordinates analysis (PCoA) based on unweighted UniFrac distances of OTUs. Each symbol represents a single WT or Gpr109a^−/− colon sample (n = 3 for both). (B) Comparison of phylum-level proportional OTU abundances in WT or Gpr109a^−/− colon samples (n = 3 for both). (C) Representative proportions of OTUs classified at the phylum level (n = 3 mice for each). ^*p < 0.05. (D) Heatmap depicting the OTU abundances at the phylum level within the Bacteroidetes, Firmicutes, Proteobacteria, and Verrucomicrobia. OTUs are shown as Phylum, Class, Order, Family, Genus, and Species.