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The enzymatic action of PSMA. A. N-Acetyl-L-aspartyl-L-glutamate (NAAG) is hydrolyzed to aspartate and glutamate. B. Glutamic acid is released from folate polyglutamate resulting in the release of folic acid. After successive release of glutamate, folate is released. Adapted from Ref. [10] with permission. Copyright 2016 Elsevier.
