Table 1.

Significant associations of single-nucleotide polymorphisms (SNPs) with DNA methylation of genes involved in lipid metabolism.

Study	Gene	SNP	CpG site	CpG site positions	Technique
Yiyi Ma et al	APOE	rs405509	cg04406254	CHR 19: 45407945, TSS1500	Infinium Human Methylation 450K BeadChip
	ABCA1	rs2246293	cg14019050	CHR 9: 107690770, TSS1500
Timothy D et al		rs174537	cg27386326	CHR 11: 61587980, Intergenic region	Infinium Human Methylation 450K BeadChip
	FADS1	rs174537	cg16213375	CHR 11: 61584727, TSS200
			cg10515671	CHR 11: 61585899, TSS1500
	FADS2	rs174537	cg19610905	CHR 11: 61596333, Gene body
Petr Volkov1 et al	CETP	rs1800775	cg02254551	CHR 16: 56998544, Gene body	Infinium Human Methylation 450K BeadChip
		rs3764261	cg26916607	CHR 16: 56994770, TSS1500
	APOA5	rs2266788	cg12556569	CHR 11: 116664039, TSS1500
	FADS2	rs1535	cg19610905	CHR 11: 61596333, Gene body
	ACADS	rs2066938	cg21721566	CHR 12: 121163144, TSS1500	Infinium Human Methylation 450K BeadChip
			cg24768164	CHR 12: 121163261, TSS1500
Bastien Vallée Marcotte et al	IQCJ	rs2044704	cg16975599	CHR 3: 158962761, Gene body	Infinium Human Methylation 450K BeadChip
	NXPH1	rs2349780	cg06056929	CHR 7: 8476128, Gene body

The Infinium Human Methylation 450 BeadChip was used to estimate DNA methylation level in these four studies. The CpG sites mean the locus identified from the Illumina CG database. The CpG site positions refer to the genomic location in relation to the nearest gene including genomic regions TSS1500 and TSS200 (1500–201 and 200–0 bases upstream of transcription start site (TSS), separately), gene body and intergenic regions according to genome build 37. APOE, apolipoprotein E; ABCA1, ATPbinding cassette subfamily A member 1; FADS1 and FADS2, fatty acid desaturase 1, fatty acid desaturase 2; CETP, cholesteryl ester transfer protein; APOA5, apolipoprotein A5; ACADS, encoding acyl-CoA dehydrogenase; IQCJ, IQ motif-containing J; NXPH1, neurexophilin-1. CHR, chromosome.