Table 2. Logistic regression analysis of associations between rs1799750 polymorphism and risk of knee OA.
| Genotype | Cases* (n=308) | Controls* (n=404) | OR (95% CI) | P | ||
|---|---|---|---|---|---|---|
| n | % | n | % | |||
| 1G2G vs 1G1G | 154/76 | 50/24.7 | 201/139 | 49.8/34.4 | 1.40 (0.98–1.99) | 0.059 |
| 2G2G vs 1G1G | 76/76 | 24.7/24.7 | 61/139 | 15.1/34.4 | 2.28 (1.47–3.53) | <0.001 |
| 2G2G + 1G2G vs 1G1G | 230/76 | 74.7/24.7 | 262/139 | 64.9/34.4 | 1.61 (1.15–2.24) | 0.005 |
| 2G2G vs 1G2G + 1G1G | 76/230 | 24.7/74.7 | 61/340 | 15.1/84.2 | 1.84 (1.26–2.68) | 0.002 |
| 2G vs 1G | 306/306 | 49.7/49.7 | 323/479 | 40.0/59.3 | 1.48 (1.20–1.83) | <0.001 |
Bold values are statistically significant (P<0.05).
*
The genotyping was successful in 308 cases and 404 controls.